When Are These Surprises Going to Stop?this week it was with long RNA that is circular.
Evolutionists once dismissed these long, circular RNA macromolecules—which can be thousands of nucleotides long—as rare genetic accidents or experimental artefacts. Now circular RNA appears to be, err, an abundant and crucial part of genetic regulation. There are thousands of them, probably fulfilling a multitude of functional roles in what one evolutionist admitted is “a hidden, parallel universe” in the molecular world.
And amazingly the genes encoding these RNA macromolecules often overlap with protein-coding genes. Recall that protein-coding genes, in addition to coding for an incredible protein machine, may also contain several more layers of information encoding signals for the transcript (mRNA) stability, mRNA editing, DNA copy error correction, the speed of translation, the protein’s three-dimensional protein structure, the stability of that structure, the multiple functions of the protein, interactions of the protein with other proteins, instructions for transport, avoiding an amyloid state, any other genes that overlap with the gene, and controlling tRNA selection which can help to respond to different environmental conditions.
That is a tall order and now we have yet another layer of information for which genes much encode: circular RNA macromolecules which just happen to interact with microRNA and which just happen to be expressed at the right time, because if they are expressed at the wrong time you don’t have a normal brain. And amazingly, in protein-coding genes, circular RNA macromolecules may be encoded both in the antisense strand and in the sense strand. In fact numerous circular RNAs form by head-to-tail splicing of exons.
Not surprisingly, beyond “oh, evolution did that,” evolutionists have no scientific explanation for how circular RNAs could have evolved. As one evolutionist admitted, “You just wonder when these surprises are going to stop.”