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I would love opinions http://www.amazon.com/Cellucor-Alpha-Amino-Supplement-Count/dp/B00HM9OJFYAnonymoushttps://www.blogger.com/profile/09796769808901979417noreply@blogger.comtag:blogger.com,1999:blog-3855268335402896473.post-10843617732537662292015-07-06T14:27:34.515-07:002015-07-06T14:27:34.515-07:00Great Post! anybody ever try this amino acid? I wo...Great Post! anybody ever try this amino acid? I would love opinions http://www.amazon.com/Cellucor-Alpha-Amino-Supplement-Count/dp/B00HM9OJFYAnonymoushttps://www.blogger.com/profile/09796769808901979417noreply@blogger.comtag:blogger.com,1999:blog-3855268335402896473.post-62774413853446711012015-05-30T12:34:29.518-07:002015-05-30T12:34:29.518-07:00Allan:
There's no evidence that transition/tr...Allan:<br /><br /><i>There's no evidence that transition/transversion bias has been taken into account</i><br /><br />Evolutionists commonly make these sorts of "there's no evidence ..." statement as though they mean something. There's no evidence he has stopped drinking. Ah, haa, very interesting.<br /><br />If you are looking for something that has "no evidence," it would be that transitions and transversions created the DNA code. The shell game is to get you to swallow the camel, and pretend that transition/transversion bias is a confounding factor that can explain the code's optimality. Cornelius Hunterhttps://www.blogger.com/profile/12283098537456505707noreply@blogger.comtag:blogger.com,1999:blog-3855268335402896473.post-57393326475084801092015-05-30T12:18:30.293-07:002015-05-30T12:18:30.293-07:00I should point out that his first article is from ...I should point out that his first article is from 1985 Jacobhttps://www.blogger.com/profile/07099500455962505463noreply@blogger.comtag:blogger.com,1999:blog-3855268335402896473.post-776308693437575572015-05-30T12:17:07.974-07:002015-05-30T12:17:07.974-07:00Good luck getting him to admit this.Good luck getting him to admit this.Jacobhttps://www.blogger.com/profile/07099500455962505463noreply@blogger.comtag:blogger.com,1999:blog-3855268335402896473.post-70869925600345954462015-05-21T10:11:37.120-07:002015-05-21T10:11:37.120-07:00You need to take account of potential confounding ...You need to take account of potential confounding factors that bias distributions away from 'random' expectations. There's no evidence that transition/transversion bias has been taken into account, for example. Fourfold degenerate sites are less susceptible to this than twofold or singlet sites. Over time, this would lead to under-representation of the latter, since these substitutions are not silent. And certain amino acids are just less generally substitutable than others. <br /><br />This seems a classic case of a conclusion in search of some supporting data. AllanMillerhttps://www.blogger.com/profile/05955231828424156641noreply@blogger.comtag:blogger.com,1999:blog-3855268335402896473.post-79356021412690138092015-05-20T09:06:38.432-07:002015-05-20T09:06:38.432-07:00I learned that over the years there were attmpets ...I learned that over the years there were attmpets to make a universal computer programming language. There was PL/1, ADA, ect. It seems that there are advantages to having a universal code. So maybe there are good design reasons for having a universal genetic code as well. For example if horizontal gene transfer is an important phenomenon then a universal code is required. There needs to be portability across platforms, just like with computer programs.natschusterhttps://www.blogger.com/profile/13127240463824366637noreply@blogger.comtag:blogger.com,1999:blog-3855268335402896473.post-35640396705328127322015-05-20T00:55:03.718-07:002015-05-20T00:55:03.718-07:00Okay, that first citation is one you've used b...Okay, that first citation is one you've used before - it's in French, and it's a one line abstract. Please stop using it if you can't provide a translation and/or an explanation.<br /><br />The second one is quite interesting - and I've read it twice this afternoon, and still don't have a good grasp on it. One thing I *CAN* say about the study is that it actually takes into account the DEVIATIONS from the expected frequency. So for example, there are 61 out of 64 codons that can be used, and if a particular amino acid has 6 codons, then you would expect it to make up roughly 9.8% of the sequence. If in practice, it makes up 8.5% of the sequence, then it is that 1.3% difference that is measured in the paper.<br /><br />I'm a bit concerned that taking into account the amino acid frequencies is a little bit circular, but I'll need to sleep on it ...Glennhttps://www.blogger.com/profile/03419669114209732527noreply@blogger.comtag:blogger.com,1999:blog-3855268335402896473.post-90985196709454668502015-05-19T22:53:17.560-07:002015-05-19T22:53:17.560-07:00Interesting, thanks Glenn. I think what you are se...Interesting, thanks Glenn. I think what you are seeing there is the evolving sentiment from the earlier "proteins are slightly edited random sequences and the genetic code is a frozen accident" to the realization that the code is unique and performs a set of specialized functions simultaneously.Cornelius Hunterhttps://www.blogger.com/profile/12283098537456505707noreply@blogger.comtag:blogger.com,1999:blog-3855268335402896473.post-81969098998930136782015-05-19T22:11:05.077-07:002015-05-19T22:11:05.077-07:00I've been able to get a hold of a later versio...I've been able to get a hold of a later version of the textbook - "Genes X".<br /><br />In "Genes VII" it says, and I'm quoting your comment above, that:<br /><br />"There is only a slight tendency for amino acids that are more common to be represented by more codons, and therefore it does not seem that the genetic code has been optimized with regard to the utilization of amino acids."<br /><br />In the later version, "Genes X", it says:<br /><br />"In general, amino acids that are more common are represented by more codons. This suggests that there has been some optimization of the genetic code with regards to the utilization of amino acids."<br /><br />Thoughts?<br /><br />Glennhttps://www.blogger.com/profile/03419669114209732527noreply@blogger.comtag:blogger.com,1999:blog-3855268335402896473.post-68621896460320591252015-05-19T19:32:25.800-07:002015-05-19T19:32:25.800-07:00no such optimisation exists - that's quite cle...<i>no such optimisation exists - that's quite clear in the graph.</i><br /><br />http://www.ncbi.nlm.nih.gov/pubmed/3933772<br />http://www.ncbi.nlm.nih.gov/pmc/articles/PMC60310/<br /><br /><br /><i>You need something that's NOT that graph</i><br /><br />The similarity is that both are codes and both reflect the letter frequencies of the messages they encode.Cornelius Hunterhttps://www.blogger.com/profile/12283098537456505707noreply@blogger.comtag:blogger.com,1999:blog-3855268335402896473.post-87799695633976710612015-05-19T17:02:21.604-07:002015-05-19T17:02:21.604-07:00Wow. I do recall that you tried to pull me up once...Wow. I do recall that you tried to pull me up once on formal logic, so your response surprises me.<br /><br />You are the one claiming an optimisation analogy exists between Morse Code and the codon table. I am saying that no such optimisation exists - that's quite clear in the graph. You need something that's NOT that graph, because the graph roughly reflects the codon frequency *IF* the underlying DNA is random. That's why I was questioning whether my brain was working properly earlier because the entire post seems to be completely upside down.<br /><br />This is NOT the same as me saying that proteins are just strings of random DNA - clearly they have a specific function which degrades as you change the sequence, and most random strings of amino acids wouldn't fold into anything. This is not necessarily a function of the relative frequencies of amino acids - that's the point of difference. <br />Glennhttps://www.blogger.com/profile/03419669114209732527noreply@blogger.com